Computer-assisted drug design allows for a more rational approach to understanding protein chemistry and drug design. While this has remained a challenging field, it is still a cornerstone of pharmaceutical research and can lead to dramatic improvements in SAR on a shorter time-scale than any alternative. Boulder Bioconsulting includes experts in the theory and practice of modern structural modeling, docking, protein chemistry, and CADD, and we have a track-record of success in finding SAR options that internal resources at our customers have missed.